Enclomiphene for Low Testosterone
Enclomiphene is an oral treatment that prompts your body to produce more of its own testosterone, rather than replacing it from outside. It is taken as a tablet, usually 25 to 50mg daily depending on your treatment plan. Because it is not a controlled medication, we can prescribe it in all 50 states and the District of Columbia.
What is enclomiphene?
Enclomiphene works on the signalling pathway that tells your body how much testosterone to make. By blocking estrogen’s feedback signal at the brain, it prompts the pituitary gland to release more luteinising hormone (LH) and follicle stimulating hormone (FSH) — the hormones that instruct the testes to produce testosterone.
The result is an increase in your own natural testosterone production, rather than testosterone introduced from an external source.
How is enclomiphene different from testosterone replacement therapy?
Testosterone replacement therapy supplies testosterone directly, by injection, cream, gel or long-acting pellet. Because your body detects the external supply, it reduces its own production while you are on treatment.
Enclomiphene does the opposite: it stimulates your own production. The practical differences are:
- It is taken orally as a tablet, rather than injected or applied
- It maintains the body’s own testosterone production rather than replacing it
- It does not carry the same suppression of sperm production, so it is often preferred by men concerned about fertility
- It is not a controlled medication, so it is available in all 50 states
Which is appropriate depends on your results, your goals and your medical history. That is a decision for your physician after your blood work.
Does enclomiphene affect fertility?
This is the most common reason men ask about it. Testosterone replacement therapy can reduce sperm production, because the body slows its own hormone signalling while receiving testosterone from outside. Enclomiphene works by increasing that signalling instead, and is therefore often chosen by men who wish to preserve fertility.
How is enclomiphene taken?
Enclomiphene is taken as a tablet. The dose is usually 25 to 50mg daily, depending on your treatment plan. Your physician will determine what is appropriate for you based on your results and medical history.
Who is enclomiphene suitable for?
Suitability is determined by your blood work and your physician’s assessment. It is frequently considered for men who have clinically low testosterone and who want to preserve fertility, prefer an oral treatment, or live in a state where testosterone therapy is not available to them.
Can I get enclomiphene in my state?
Yes. Enclomiphene is available in all 50 states and the District of Columbia, because it is not a scheduled medication.
How do I find out if it is right for me?
Start with a free consultation and blood work, which costs $99. A licensed physician will review your results and discuss whether enclomiphene, testosterone replacement therapy, or neither is appropriate for you. Your physician will also discuss the benefits and risks of any treatment before you begin.
Call 1-800-530-7746 or book a free consultation.
Related reading
For independent information on this topic, see the National Institute of Diabetes and Digestive and Kidney Diseases.
Medically reviewed by John Webb, MD, MBA on 28 September 2026. Dr. Webb completed a men’s health (Andrology) clinical research fellowship at Harvard Medical School and has nearly 20 years of experience in progressive healthcare leadership.
This page is general information and is not medical advice or a substitute for consultation, diagnosis or treatment by a licensed healthcare professional. Hormone therapy is available only following an evaluation with a licensed Prime Men’s Health provider, who determines eligibility and explains benefits and risks. Depending on federal and state regulations, your treatment plan may require an in-person physical examination.